being high in refined sugar does, which most sodas are.
high amounts of refined sugar definitely isn't good for you. the process of refining it in the first place takes out the goodness that natural sugars have.
I assume you mean HFCS. Definition from Wikipedia: "High-Fructose Corn Syrup (HFCS) comprises any of a group of corn syrups that has undergone enzymatic processing to convert some of its glucose into fructose"
Table sugar, sucrose, is "[a] molecule [that] is a disaccharide composed of the monosaccharides glucose and fructose with the molecular formula C12H22O11."
Essentially, after a first step of enzymatic processing, they're both glucose and fructose. The first step of enzymatic processing does not give you superpowers when you go through it. Really, there's no health difference.