I can build without looking at the keyboard. But I customized all my controls a while ago. Nothing the same as most of you. (My controls: O = shift brick forward, L = shift brick back, > = shift brick right, < = left, I = shift brick up, K = shift brick down, 0 = shift brick up 1 3rd, 9 = shift brick down 1 3rd, "=" = rotate CCW, - = rotate CW, Shift = plant brick) :D
Those controls are so natural to me now. I can nearly build without looking at the screen. (Nothing complex, mind you)
Plus it makes transitions to a laptop much easier when building because all the controls still work. That's good for me because I switch between my laptop and desktop quite often.