MAOIs in general aren't a good thing to combine with drugs, but if you're going to consume (drink) DMT you've got to take a MAOI (already in Ayahuasca) for it to work, and it's pretty safe with DMT. Just make sure it's the only drug you do if you do decide to drink Ayahuasca. If you're down to smoke it though, may as well just do that.