An experiment I've been interested in trying is performing an enzyme induction on CYP2C9 prior to consumption of THC/cannabis in general, and then for comparison an inhibition of enzyme CYP2C9. Theoretically inducting CYP2C9 should help someone like weaver (or myself) overcome the overwhelming feeling that large amounts of marijuana has on them. In the same way, inhibiting CYP2C9 should increase the effects of marijuana.
Induction would also shorten the length of the high, where as inhibition may lengthen the high.
This paper shows that induction of CYP2C9 may be achieved with the chemical hyperforin which can be extracted from
St. John's wort. St. John's wort can be purchased OTC at many natural health stores, and may remedy feelings of being 'too high' if taken 2-3 hours before consumption of marijuana.
Alternately, tagament is a CYP2C9 inhibitor. I've looked for a better (OTC) inhibitor, but that's just about the best one I can find. Prozac is another inhibitor of the CYP2C9 enzyme.
Oh well. If I was in grad school for neuroscience right now, that's actually probably the topic I'd write my thesis on. The Effects Of CYP2C9 Inhibition and Induction On The Psychopharmacological Effects of Cannabis in the Human Body.
TL;DR if you wanna get higher take prozac, if you wanna get less high consume St. John's wort. tell me results pls (& if you die not my fault)