When the dog died in Fable 2. When Fable 3 deleted my past end-game save. Generally anything important in Skyrim (i literally cried like 5 times playing through skyrim the first time, mainly when the general slaughtered the dirty-lying-rotten-friendrice piece of stuff ulfric stormcloak) When the chick killed the guy in the walking dead when he saved ben (y do i only remember the name of the annoying college kid that i hated that whole game) When I nuked japan in Civ5.