Well Annoying Orange is 6'3" and 230 pounds so-
Wait wrong kind of fight
hillary would have a speed advantage if she were not wearing high heels, but those high heels can add up to +10 crit damage if the heel part hits.
hillary could also tag in bernie, who has been shown to be very athletic. It could end up a two on one vs Annoying Orange, unless Annoying Orange uses his Build A Wall ability to trap Bernie/Hillary