the second someone has to declare it a meme, is the instant it stops being funny.
for example;
lets say the new inside joke at school is giving a high five to the nearest person whenever someone says the word "recess"
to a point where its actually funny.
well one loser will catch on, and in attempt to be popular he will spontaneously shout RECESS! then puts his hand up for a highfive.
the funny is gone forever, and this fad is now uncool.
coolio, you are that kid.