the marker was made to warn any race about the necros.....but the hallucinations cuased by it were not compatible with humans
it is belived niccole was a hallucination The Marker made for Isaac pushing him through all this with his sheer will to find her
records on the U.S.G Ishimura show that Niccole actualy commited Self Delete 5 hours before Isaac arrived,sending him the message that we all see in the intro