Man, when I first played FO3...It was like extreme ecstasy. It's like that for all that play it, but it simmers down after a while and you don't feel like playing it much anymore.
I have what-Atleast over 2000 of every bullet, 300 missiles, 9 mini nukes, around 200 alien ammo, around 400 stimpaks, absurd amounts of drugs, and 12k bottlecaps.
The game gets waaaay to easy after level 10. Now the only trouble I have is fighting Feral Ghoul Reavers (In my opinion one of the most absurd enemies in a game...oh my god). Those cigaretteots take hideous amounts of damage and I usually encounter them in pairs. Infact i'm prone to just running from them because I don't even want to put up with them.
There should have been an option to make supplies alot more scarce to make it harder.