Well no matter how careful you are you will end up getting bitten eventually.
Sharkmesh could be a temporary alternative to dying. If the teeth can't break the skin, no bite. And in this scenario, the real danger would be other people, some would be crazy enough to shoot you on sight, then there would be the "feral" people, possibly separated from a parent at a young age, and in learning to fend for itself it has become hostile towards everyone, and incredibly dangerous.