I'm playing Rise of Nations and I named all my cities after pony ones. Right now Ponyville is a loving warzone being hit from the sea and the ground by the French, and Manehatten and Stalliongrad are suffering from raids.
Theres also been a huge thermonuclear war but Equestria has a missile shield so we ended up ok (and did some of the nuking)
God help us...
EDIT: The Ponyville Library has been destroyed. Military instillations have been set up and we can only assume that Twilight Sparkle has died