I thought of an interesting situation while reading the "Weird Stuff You See on deviantArt" thread:
You are a popular artist on deviantArt. You can draw mostly anything with virtual ease and do it pretty well to boot. One day, you receive a personal message from a user asking you to draw a picture to satisfy some crazy special interest you can't stand. However, he adds that he will pay you a substantial amount of IRL money if you do it for him.
Would you take the commission?
Addendum: It's the special interest you hate/find repulsive the most, but he's paying $40+ depending on how well you do.