Well it really depends, depending on what instructions are being executed.
Generally I wouldn't compare such CPUs unless you have more information such as how many registers there are in the register file, different mathematical capabilities within the ALU and lots of misc technical stuff relating to decoding and executing instructions and sending out data.
Out of personal preference and knowing CPUs, I would go with the 16-bit CPU. Also are you actually talking about micro-controllers instead of CPUs because that sounds like a micro-controller (which has additional features to consider).
Just looked it up, it's often used in micro-controllers but it's a complex-instruction-set-computing CPU using some sort of obsolete standard regarding architecture style.