It's still noticable. That minor delay really shows when playing.
Saying "no" for a response which is perspective relative is a bit silly.
Uh that's like 5 times less than the average human reaction time in ping difference.
You don't notice. You can't notice. It's 40 milliseconds. 0.04 seconds. It happens 25 times every second.
Just try doing something, ANYTHING 25 times per second.
P.S. Everytime you blink 40 milliseconds pass 10 times.