If you want to take your mind off of an anime or two, watch One Piece. It's totally unrealistic (in a realistic way, if you know what I mean), and they keep the humor going, even through the fighting parts. It's also currently over 600 episodes, so it'll keep you busy for a while. Yes, it is one of those anime where they repeat the last five minutes of the previous episode at the beginning of each episode, but once you get used to skipping past it, it's a bit better (although some of the arcs still take too long).
Anyway, it's (hopefully) an anime that's original enough to keep your mind off of things.