Yes.
Those saying no are simply unaware of network security. However, the ODDS of it happening are very, very slim. Most people forward ports, most do not get viruses 'sent' to them. Supposing a port is forwarded, that only gives 'hackers' a means of accessing your computer. All they could usually do at that point is attempt to exploit something you're running. As long as your programs are all properly updated (including Windows), you'll be fine.
Espically considering a 'hacker' has to specifically target you in order for this to happen. And has to find the port you've forwarded (most portscanners stop at about 1k-2k). And most real hackers don't care about small-fry, anyway.