There aren't many major centers in Missouri beside St. Louis and Kansas City. I mean there is also Joplin, but sometimes I wonder how the city hasn't been wiped away yet.
We have St. Louis, Kansas City, Jefferson City, Kirksville, Columbia, Springfield, Joplin, Branson, St. Joseph, Cape Girardeau, and Poplar Bluff just off the top of my head. I'm pretty sure all (or most) of those have 50,000+ people.