Well, looking at my toothpaste, it's 0.298% sodium fluride. It's a very low amount.
You would be safe as an adult to directly consume several tubes (at about 100ml a tube) before suffering from poisoning.
I'm not advocating that we regularly consume large quantities of toothpaste, but for a fully-grown man, 1 tube isn't going to kill you.
And Adult Swim didn't reward Tony because it is dangerous, but because it is disgusting/weird.
But IMO, there's nothing all that disgusting about eating a tube of toothpaste compared to eating lots of other things, including a sloppy tin of dog food.