some apps were made to only run on 32,
but in 64 vista it creates 2 program folders

what you heard is people complaining about outdated software or small 3rd party developers having these issues.
but its been long enough, most companies got their stuff together now.
that (x86) use to say x32, but some other program i recently installed renamed it lol.
i haven't had a problem yet
note: vista x86 is 32bit, and lesser then ultimate