I hate McAffee. I had been using it since the early 90s, since I could get a cheap subscription through AOL. A few years ago I learned about AVG, and figured I'd start using it as soon as my registration for McAffee expired. I did and I've never had a problem with it.
Issues I've had with McAffee over the years:
McAffee provided a free firewall hidden in their program I didn't know about and blocked IRC communication.
They decided to duplicate windows system restore, now I've got a drive partition I didn't want.
Bloated with features I never used and had to disable in some cases.
AVG, Spybot Search and Destroy, a good router to use as a firewall, a secure browser and common sense has kept me virus free for several years now.