I just went into this Vault and it really creeped me out, and the practically pitched black vault made it even worse. Basically in Vault 106 the Overseer put this psychological drug into the air vents and the inhabitants went crazyand killed everyone who was unaffected. The insane vault dwellers are still in the vault and attack you if you go in. The drug is still flowing too, and you get affected by it. If you continue walking down into the Vault your screen starts getting blue and you start hallucinating. In one of the hallucinations you go up to one of the Vault computers and theres a document titled "Message to self". It says to breath in the deep blue and it keeps updating with messages. The hallucinations end and as you continue further you start seeing hallucinations of your Vault 101 companions such as Butch and others. As you go down further someone named "Survivor" tries to kill you and in the middle of battle you get hallucinations of Butch and his friends trying to kill you. When you kill the Survivor everything stops and there's skeletons everywhere. If you have this game do this quest, now.
tl;dr: Vault 106 is creepy as forget, go do this side quest now.
Discuss this and other vaults.