Menu controls for PC suck roosters
If you've rebound keys, for instance, swapping F and R (they're reversed as to how they are in Oblivion, R to sheathe/unsheathe weapons and F to change camera viewpoint by default, so I swapped them back), then in menus their actions will be swapped but it still says the same keys at the bottom.
F to favourite, R to drop. If you've swapped F and R, that's actually F to drop and R to favourite. It doesn't update to reflect this.
Also, the menu items are fiddly; sometimes in shops you can hover over one without it actually highlighting, and clicking when this happens exits the shop menu. Really really annoying.
Aside from that I've noticed a fair few minor cosmetic bugs (missing interior faces on a few helmets, seaming on the Jarl of Whiterun's right forearm when he moves his hand around) but it hasn't genuinely crashed once yet. It hung on quicksaves a couple of times but hasn't done it for like four hours and I quicksave constantly.
Crafting is pretty cool; even at low levels you can add two damage to most weapons with upgrades. Crafted gear isn't redundant and unworthy of use. The alchemy system is pretty cool too, having to discover effects by experimentation. Disenchanting items to unlock enchanting effects is also pretty cool. I've not been able to find how to smelt bars of metal from ore yet though - it's not at the blacksmith's forge.
Also, you can play hide and seek with the children.