Nope, it can support 2 monitors and it doesn't matter the resolution
Two monitors at different resolutions =
major screw-ups
I've tried 3 monitors with a friend's build, and one of them was 1600x1050 while the other 2 1920x1080p, and it was really... can't find the word to say it.
Also, two monitors wouldn't be good for gaming. The end borders on each side of the monitor would obstruct your central view.