Play the demo!The Binding of IsaacThis is a game developed by Edmund McMillen and Florian Himsl, in which you control the protagonist Isaac. Cast into the depths below the floorboards of his bedroom while running from his deranged God obsessed mother out to sacrifice him, Isaac journeys through different stages collecting hundreds of different items that make him stronger. The items play a major role in the game, so check out the wiki
HERE for a list of items, their effects, and reference pictures.
The game itself is very Zelda-esque, in that you play room by room and once defeating a stage boss, you advance to a different, more difficult floor.
I am totally addicted to this game (almost 70 hours logged on steam), I've beaten it 6 (i think) times and it just got harder. Actually, at one point the game DOES get harder. Awesome, right? Yeah it's forgetin' tough.