As far as I know Fallout 4 is probally going to play in the Mojave desert again and since Caesar's legion is going to play a big role in it , it might play around Arizona or something. But what I would like to see are things like :
1. Better relationships in characters like in Fallout 3 but with more improvements. I want some characters that are close to the main character and are worth not to be headshotted.
2. Still having the ability to kill EVERYONE ( in Fallout 3 you couldn't kill the elder of the Brotherhood , Amata and your Dad which seriously botherd me)
3. A better shopping system ( Why should the gun runners buy every single piece of scrap you give to them ?)
4. Everything that New Vegas improved including : expended characters for companions , unique weapons are way more "unique" , gambling , special melee attacks , ironsights for weapons , weapon mods , bigger variety of animals ( young , adult etc.) and more.
5.Better faction wars. ( Seriously factions in NV barely fought each other and you had to go in their bases where they were all sitting with their thumbs up their asses in order to finally kill some of them.)
6.Better free roaming than in in F3 and NV ( If you go far west in Fallout 3 you were raped by deathclaws , in NV if you go north or into any mountain areas you you get raped by cazadores or deathclaws which heavily limits the ability to move at the beginning of the game)
1. bring back the Dart-Gun from fallout 3
No that thing was way too strong against deathclaws. It made them to no threat at all.