O.o is supposed to look like one eye is bigger. It's like a What the forget? face where you raise one eyebrow more than the other, making your eyes look bigger.
When I raise an eyebrow, my eye does not enlarge itself. Consider the fact that both eyes are equally as round. This means that they are both open at an equal amount. This means that the one eye is not just enlarged vertically, but horizontally as well. An eye does not expand horizontally when it's opened more.
It's a mutant.
.-. is an upside down face, including the body.
They're so awkward that they're upside down.
I'm going to be blunt about this.
That's incredibly handicapped.