The Humble Store is a new way to get games at very low prices while supporting charity. The deals change every 24 hours, knocking huge chunks off the normal price and splitting the profits 75/10/15 for the developer, charity (including American Red Cross, Child's Play, and the Electronic Frontier Foundation), and Humble themselves, respectively. Many games also come DRM-free, be sure to check the Store for more details.
The debut sale includes
Don’t Starve, Prison Architect, Rogue Legacy, Euro Truck Simulator 2, Natural Selection II, The Swapper, Chivalry: Medieval Warfare, Orcs Must Die! 2 and Gunpoint, each available separately and only until the deals change in less than 24 hours.
This isn't the end of the Humble Bundles and Weekly Sales, though! Those will continue as usual.