So i have High brow, cursed, "Its in the cards", Slow roll, and Computer savy all done.
Cursed was kinda a challenge and "Its in the cards" got a little tough near the end, though i found out what "Credit card" and that little stone does. That thing is amazing.
EDIT: Just beat Issac. I was maggy. Things were looking pretty bleak mostly through, got the fire rate odd mushroom and anti gravity, which was good until i fought a black demon boss wrapped in bandages in the necropolis. Would have been easier if i went to the item room first, because inside was polyphemus.
With that, everything was kinda a breeze, but everything got even better when i found crickets head and book of belial, which just made the game right there. got to isaac safely with and emperor card. Also, the Trinity Shield is OP. Makes all the bullets spammers easy. Isaac, unlike moms heart, is kinda easier now, or that just might be the shield/Polyphemos talking.