my genetics are highly in favor of neural adaptation as opposed to hypertrophy, so i don't run into too much trouble with clothes other than:
1. half the shirts i find in my size aren't comfortably wide enough for my shoulders. i refuse to go a size up b/c the sleeves would be too spacious and the torso would be too loose
2. i also have a hard time finding pants that fit my crotch and fabulous ass - tapered pants definitely work against the baggy calf issue, but when i'm lucky enough to find them the price tends to be high