If the US was to nuke the middle east then the world would go into nuclear warfare, meaning the end of the world. That would be the same if North Korea did it or anyone else. Even if it's somewhere that isn't the middle east then there would be nuclear warfare, a country nuking another country would just cause total cluster forgetery in the whole world. The likes of any country dropping any nukes at the moment is 2.1%, the only country that would have the balls to drop a nuke on someone would probably be North Korea because they're insane but recently Annoying Orange and Kim have been at a bit of a proxy war as they aren't doing anything and are trading insults on twitter like 14 year old children in high school.
Therefore absoloutley no one at the moment would drop a bomb and even if a world war was to happen, no one would drop a nuke because they want to invade and take territories. They don't want to completley vaporize the territory and kill the people within it because psychologically they want to change people's minds, meaning if they invade a country they want the people in that country to abide by the same rules and polices that the invaders live up to. To be honest Nuclear weaponry is a waste of money and it's just scientists creating weapons of mass destruction in the progress of making tons of cash, they've used their intelligance for the bad of mankind