They'd all vomit, air filters would clog up, they'd die.
You need to press a serious of buttons and levers to get through earths Atmosphere without burning up.
Not during liftoff. And re-entry is mostly getting a specific angle for the ship to come in at, not 'buttons and levers', IIRC.
Also, if the space shuttle / Soyuz burned up in re-entry then bodies sure as hell would burn up too.
Easy answer.
They wouldn't know how to fly the ship, get pulled in by Earth's Gravitational Pull
and crash...
in the middle of New York City...
If they didn't know how to fly the ship, they wouldn't be able to lift off.
And how would Earth's gravity pull it several thousand miles from French Guyana/Florida/China/Russia/India and crash it into NYC?