But really, without smallpox the white man would have got curb stomped by the natives. All of us non-natives owe a little something to that little disease (if you ignore the millions of European deaths it caused too).
If Native Americans can beat an army of trained men with guns, you know you're screwed. Native Americans had such primitive weapons, made of stone, wood, and animal bits. They could do amazing things with a bow, I myself find it hard to hit a target beyond 20 feet, but some could snipe even the smallest thing.