How would a plague only not-effect people who have played a building game?
The joke-----------Your head
The certain alignment of pixels in the main menu's slideshow of screenshots alters our DNA to be resistant to this plauge when we look at it; because of the light entering our eyes is proccessed into premature sheep embryos that are ripped to pieces and stored in our immune system, which immidiently kill any germs related to this disese, therefore keeping us alive.
I would meet all the Grammer national socialist's and kill them!