I don't think making any games past Skyrim can be done without loving over the lore since one of Skyrim's major quest lines involves you completely changing the course of the entire land.
You either make one path cannon or stick with linear stories.
I've thought about that, and now with Akavir an idea suddenly popped into my head.
With the history of Tamriel now unable to be built upon, unless they use Mass Effect type story line that is affected by previous games. They might not make another game, but what if they
did put the next one in Akavir. It'd be perfect, with a severed connection between the two continents, you wouldn't need the new game to follow the lore of Tamriel at all. It'd be completely different, new races maybe some old ones as-well. Among other things.
Still wish they would do it in Elsweyr though. :P