from a design point of view, that's much easier to work with on all sides. consider as well that the enemies have to have a degree of procedural generation to them. if they can pull it off, i don't think there's much a problem. i didn't notice until you pointed it out, and even then i had to look for awhile. of course, someone with more experience in pixel art like yourself would likely be able to spot this kind of thing a mile away so what do i know NOTHIN that's wat bustre...
it's most noticeable on the tail and neck i think. it's goofy in areas where shading doesn't change when it probably should