A role-playing game focused on Europe's imposition of imperialism on a chain of mythological Asian islands, set at the dawn of the Industrial Revolution. You'd be vagabonding through a rural land presided over by local deities attempting to oust those who do damage to their territory. It would be a game that was quirky at times and serious at times, and that emphasized economics, mystery, and exploration moreso than conflict.
Additionally it would emphasize your fragility. You're a human being who is simply trying to survive, and you're only here for so long. A woods full of wolves with a mysterious deity that comes out at night to eat souls is actually dangerous *cough* Skyrim *cough*. You'd have to find a guide or something and head out a daybreak, hoping your wagon doesn't break down and leave you scared stuffless when night comes.
You'd have to trade currencies and avoid being screwed over by merchants. If they do screw you over, then you can stab them in the back during the middle of the night, be found out, and be burned at the stake the following Sunday!