Actually.. (SPOILERS; Transparent text below)
If you chose the right choice and Roman lives, he'll call you after a bit and tell you Mallerie is pregnant with twins.
Also in GTA V at the start of the trailer saying;
"He's not staying the night, he's a boy!" and the teenage girl going "Oh my god!" so basically there are technically kids
also niko says he always wanted to be an astronaut when he was a kid.
They say: "He's NOT staying the night, he's a
bum!", not boy.