I was just there oh my gaaaaaaawd
Its so fantastic. What I would do in San Francisco is:
Go to Russian Hill. You can take the trolley there. It's touristy, but fun as hell.
Russian Hill has some seriously cool buildings; and if you like tapas, go to Zarzuela's. It's really fantastic I would recommend the sausage.
Then I'd go to Inner Richmond, just to see how boring it is.
Definitely go to the Haight & Inner Sunset, they're really nice neighborhoods. Walk around. I stayed in the Sir Francis Drake a while ago, and it was fantastic, too. Right in front of the trolley.
The Tenderloin, south of Market and Powell, is stuffty and I'm pretty sure I saw crack dealers. Don't go there.
City Lights is a good place, and there's an Italian restaurant nearby that has great gnocchi.
If you're gonna drive there, its amazing. If you're taking the PCH (Which I HIGHLY ENDORSE. Do not go any other way because its stuffty. PCH takes you up the cliffs and near the beach and stuff), go to Big Sur and eat at Nepenthe. It has great views and good food. The fries are McDonalds tier.