It's Fructose, not Sucrose. The comparison to Thalidomide is the fact that both contain an L and D isomer, which chemical with essentially the same structure, just mirrored. In the case of Thalidomide, one isomer produced the desired, good effect, while the other isomer caused horrible birth defects. In the case of Fructose, one isomer just behaves like any sugar, but the other produces subtle changes in body chemistry making you more receptive to the trash that corporations feed you.
Wake up sheeple.

Also, haven taking AIM Chemistry in high school (and getting an A), most of this isomer stuff you keep going on about it is
mostly bullstuff. While different isomers (arrangements of atoms in a molecule) can have differing effects, in the case of thalidomide, it is simply a case of one bond being mirrored which does pretty much nothing in terms of molecular biology. Now, if the atoms were in different ion pairs, then yeah, it would be different. Anyway, fructose and glucose are indeed isomers of each other but neither are bad for you, and HFCS is essentially corn syrup with some of the glucose (not bad for you, found in practically everything) converted into fructose (found in fruit). It doesn't make it any more dangerous.
EDIT: I forgot another detail: sucrose is composed of glucose linked to fructose. HFCS is just a mixture of glucose and fructose, unlinked. In your body, sucrose is broken apart anyway, so HFCS is just already broken down (and with slightly different, but entirely inconsequential, proportions).