Literally everyone in this topic is like E. Coli and the main topic itself is room temperature roast beef.
literally
Literally everyone in this topic is like E. Coli and the main topic itself is room temperature roast beef.
Everyone is literally like a simile?
I'm sure it's not quite correct, but the sentence works. You can literally be similar to something.
Or it could be
[Literally everyone in this topic][is like E. Coli and the main topic itself is room temperature roast beef.]So, literally all users in this topic, rather than just some, fit the simile.