Wiped out the Bishop family in Fallout 2 with my bare hands, Myron the wimp, Sulik, Lenny, Cassidy, Vic, and Dogmeat (Using an Unlimited Companion mod because I'm a filthy cheater) along with the Jinxed trait because I forgot that Bishop gets pissed off to the point of murder if you plow his daughter or his wife. The self-defense massacre of the Bishops went well until I fought my way to the casino floor and then all hell went loose.
Automatic weapons blazing in the middle of a crowded casino can only go so well, especially when both parties are accidentally shooting screaming civilians left and right (and one of them carries a loving hunting rifle. Old Man Whats-His-Name, in fact). Predictably, everything got out of hand. The old man with a hunting rifle started shooting back and got shredded by the door bouncers, the rest of the civilians were accidentally gunned down in the crossfire, and several Bishop mobsters too dumb to take the hint and run for their loving lives got their eyes fisted out. It helps that the Jinxed trait made several of them destroy their own guns, shoot each other, lose their next turn, lose their ammo (making them run out of ammo even faster and depriving them of their guns, since AI can run out of ammo in this game), etc.
Goddamn, I love this game. stuff like this probably wouldn't happen in New Vegas.