Yeah, I have 4 gigs of ram with vista and at one time when I was playing I was using 75% of my ram. The game really is power demanding.
Yeah.....shame on that software for actually using a decent portion of the hardware you bought...shame!
I run this game on a custom set of medium and high settings (some don't really make a difference) and play on my widescreen monitor at 1280x 768. No AA sadly, but my 8800GT isn't that amazing.
Finished the game, was not impressed. Good enough to earn AAA status, but the game got progressively worse as it went. First there was the damn tank battle, then the fricking alien spaceship/zero-G nonsense and finally the cheesy boss battle at the end.