I say we make a topic with every skill listed and let people vote for 14 skills. The top 7 are major, next are minor.
I'd vote for axe, alteration, heavy armor and sneak for major skills. I don't care about the rest, as long as athletics, acrobatics, repair and alchemy aren't either minor or major, since they can accidentally level you without practicing any of your other skills and you miss out on the stat modifiers (except the 5x basically useless personality modifier).
I'm not interested in power leveling, but I don't want to get stuck with grabbing 1 strength, 3 speed and 5 personality every level.
I pick the tower sign a lot so I can unlock the customs office and steal all the contraband. It's not very useful after that, so someone can pick a nice useful sign.
And no gaming the system with fortify intelligence potions or infinite duration conjurations. >:(