Game Maker 7 is quite easy to learn how to use. It uses a drag and drop system, and works similarly to Blockland's events system. If you know anything about coding you can also use blocks of code, but unless you want to do some super tricky stuff it shouldn't be necessary.
SolarFlare tells me that he prefers Multimedia Fusion 2 to Game Maker, so consider that too. If you want to make a RPG, you might consider using Enterbrain's RPG Maker XP. You are basically given a template RPG and edit it from there, using a simple GUI any kid could figure out, rather than building up from scratch.