A couple.
BIONICLE: The Game - Any of the Turaga that started talking in that ye olde wise person voice telling you useless stuff you found out yourself.
Black & White 1 - Khazar and Lethys. Most annoying ally/enemy ever.
And all the quest givers.
Crysis - When you're flying that dropship through the valley and they're asking you to like do a bunch of errands for them.
"GUARD THESE GUYS"
"PICK THESE GUYS UP"
"STOP BY AND SAY HI"
"BUY SOME MILK, BUTTER AND EGGS"
Like flying a gunship to get the forget off the island isn't enough, the controls suck too.
Peppy from Starfox 64 (because it's the only starfox game I've played), always asking me to help him because he sucks.
Then Falco keeps talking about how you are terrible.
And that rabbit tells you to do a barrel roll, but that's not bad.