Holy stuff a new Fallout game! It's based on Fallout 3 but not a sequel:
The Vault: Fallout: New Vegas Portal
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Fallout: New Vegas is an upcoming game announced by Bethesda Softworks on April 20, 2009 at its London showcase. While New Vegas is not a direct sequel, it will be in the same style as Fallout 3 and will be developed by Obsidian Entertainment, a company founded by some of the developers of Fallout and Fallout 2. Based on the title, it will be set in Las Vegas. It has a projected release date of 2010 and will be available on the PC, Xbox 360 and PlayStation 3.
More about Fallout: New Vegas
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J.E. Sawyer
Josh Eric Sawyer is a video game designer active in the role playing game genre. After Chris Avellone left Interplay, he became the lead designer of Van Buren (the cancelled Fallout 3 by Black Isle Studios) before he himself left in November 2003. At Obsidian Entertainment, he is currently the lead designer and project director of Fallout: New Vegas, a standalone game based on Fallout 3's engine and gameplay.
While at Black Isle he was known for coming up with the "Ex-Presidents" project naming system. When Interplay closed down Black Isle Studios many team members ended up at Obsidian Entertainment, which would eventually come to include J.E. Sawyer.
Also 2 new DLC's for Fallout 3:
Point Lookout will be the fourth Fallout 3 add-on, to be released on June 23, 2009 for the Xbox 360 and Games for Windows Live. The PlayStation 3 version is to be released after the first three DLCs have been released. The DLC will cost 800 Microsoft points or $9.99.
Point Lookout takes place in the Fallout equivalent of Point Lookout State Park, a new swampland area filled with a main quest, and several sidequests. Its incarnation in the Fallout setting is supposedly more of a "seaside vacation town with a boardwalk" and said to have a larger landscape where "the bombs didn't actually fall, but the world has left it behind". Being designed by Joel Burgess and Nate Purkeypile, it has been stated it will have a "swampy-horror vibe" and will be the most open-ended of all DLC packs.
Point Lookout will be playable before finishing the main quest, much like Operation: Anchorage and The Pitt, which can be played immediately upon exiting Vault 101. You'll receive a radio transmission that initially starts the quest The Local Flavor.
Followers cannot follow you to Point Lookout, but you will be able to travel back to the Capital Wasteland via the Duchess Gambit anytime after arriving, which means you can spend as much time as you like exploring, and still head back home when need be. This is the first DLC to allow to break away from the quest after starting, with the exception of the Broken Steel DLC.
The swamp

The lighthouse

Hillfolk in the Trapper Shack

Character wearing Civil War Hat, and firing Repeating Rifle

Mothership Zeta will be the fifth Fallout 3 add-on, to be released in late July 2009 for the Xbox 360 and Games for Windows Live. The PlayStation 3 version is to be released after Point Lookout. The DLC will cost 800 Microsoft points or $9.99.
It won't be part of any of the Fallout 3 Game Add-on Packs, and the only disc release it will be available with is Fallout 3 Game of the Year edition.
In Mothership Zeta the aliens have returned and they are pissed. The mothership answers the distress call sent out by the alien ship at the Alien Crash Site and abducts the player, making the whole DLC take place on board of the alien ship.
The environment will be artistically different from the rest of Fallout 3, with nearly no assets reused.
Both Mothership Zeta and Point Lookout will be playable before finishing the main quest, possibly like Operation: Anchorage and The Pitt, which can be played immediately upon exiting Vault 101.