Anything that Murray says is usually hilarious.
Guybrush: What do you know about lifting voodoo curses?
Murray: Oh sure. I know a lot about lifting curses. That’s why I'm a disembodied talking skull, hanging on a spike, in the
middle of a swamp!
Guybrush: You sound bitter.
Murray: I’m sorry, it’s been a rough day.
Also:
Guybrush: If I gave you your arm back, what would you do with it?
Murray: I’d terrorize the South Seas! I’d torture the living! I’d demolish the… er… What I meant to say was, I’d use it to
pet kittens.
Guybrush: Nope. You blew it.
Murray: Drat.