so far my only complaints are
no crouching, instead we get the "stealth" mode. no non-shooting aiming while driving, you press button and it shoots so you have to quickly find your target or lose all your ammo. radio, just like in IV, has an unappealing library and you can't turn it off without shutting off all music. so far it seems like every time i have a hard collision crash, death is instantaneous and thus impossible to watch your character tumble through the air for a long distance (unrealistic, sure but less more amusing death moments if so).
none of these complaints really hurt the game, just a couple things i've noticed that differ from other Rockstar games (which isn't surprising, changing things up)