So I experienced a miracle just now
I got Inner Eye in my first item room as Cain but forgeted up big time by taking Tech 2 which left me with just the laser, slowly made my way to the Cathedral almost entirely because of Guppy's Head, Hive Mind, and Dark Matter (which was the only devil deal that didn't suck despite getting the Goat Head on Basement II) where I encountered my first slot machine in the entire run, gambled all my money away, used a Jera rune on the spoils and gambled some more, got like 3 health ups because of Eternal Hearts, and made it to the Chest
The four items inside were Spoon Bender, Book of Revelations, Chemical Peel, and D6
Took the first three, made it to the boss with relative ease, rerolled the Book and Guppy's Head before going in (Parasite and Tiny Planet unfortunately) and pulled out a win
I tend to get really defeatist and just start over when Isaac forgets me with items or if I make a terrible mistake but I really shouldn't because stuff like this can happen
