I'm playing through it currently trying hardcore mode, getting achievements (I mostly have the ones for doing specific missions), trying the Yes Man ending, and all the DLC because I never played any.
I kind of went to the Big MT too early though. I'm over the recommended level (15, i'm 20~), but those lobotomites and robo-scorpions can really take a beating. And are so damn accurate and damaging with a caravan shotgun at long range.